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Report on Cellulite reduction treatments through Dermoelectroporation

Dr. Suneil Jain, N.M.D.

Scottsdale Natural Medicine and Healing Clinic, LLC, 8390 E. Via de Ventura Blvd. Suite F-111 Scottsdale, AZ 85258

 

Preliminary Study

To evaluate the safety, tolerability and effectiveness of transdermal delivery of a cellulite reduction cocktail on Thighs, Abdomen, Gluteus & Knees through Dermoelectroporation®.

Study Design

  • Grades 1-2, some 3 were treated
  • Treatments should be administered every 2 weeks.
  • Average number of treatments 5-8.
  • Hyaluronidase /L-Carnitine/Phosphatidylcholine cocktail was delivered
  • Ultrapeel® Transderm® Meso System
  • Session number depending on the single patient's condition
  • Study conclusion on 90% or more resolution of the affected sites

 

Materials and Methods

Materials

  1. L-Carnitine - plays an important role in fat metabolism;
    shuttles long chain fatty acids across the mitochondrial
    membrane, once inside stimulates beta oxidation
  2. Phosphatidylcholine - penetrates the adipose cell, acts
    as a fat emulsifier by altering the stored lipids making them
    water soluble
  3. Hyaluronidase - naturally occurring enzyme that helps
    break up connective tissue bonds that create dimpling
    effect
  4. Ultrapeel® Transderm Meso® system from Mattioli Engineering

Methods

  • Transdermal delivery of the cocktail through Dermoelectroporation® technology:
  • 2 Steps Prodecure:
    a)Microdermabrasion
    b) When targeting adipose tissue:
    Transdermal delivery of the cocktail through Ultrapeel®
    Transderm Meso® system. In this way:
    Delivered every 1-2 weeks until desired result is achieved.
    Prepare solution using (2) 10 cc syringes. Use one syringe per respective side. Areas are referred to as abdomen,
    thighs, etc.
    Per 10 cc syringe:
    4 cc Hyaluronidase 300 units/mL
    4 cc L-carnitine 500 mg/mL
    2 cc Phosphatidylcholine 100 mg/mL

Application of proper follow up at the end.

Results & Conclusions

  • Patients were treated with the following results: Patients drastically reduced inches in weeks.
  • Transdermal delivery is possible and safe with no contraindications reported.
  • All patients showed a good level of improvement and she was so happy with results.

Jaggy Rao, MD* , MD Division of Dermatology, University of Alberta Edmonton, Alberta, Canada

 

Preliminary Study

To evaluate the safety, tolerability and effectiveness of transdermal Hyaluronic Acid (HA) delivery using Dermelectroporation®

Study Design

  • 10 healthy female subjects
  • Symmetrical periorbital rhytids
  • Randomization: Only RIGHT or LEFT face treated
  • Efficacy Parameters:
    - Photography
    - Histology
    - Blinded dermatologist assessment
    - Subject questionnaires

 

Materials and Methods

Materials

  • Hyaluronic Acid 15 mg/ml, very low viscosity from Apothécure, Inc., Dallas, Texas
  • Ultrapeel® + TransDerm Ionto® from Mattioli Engineering, Florence, Italy

Methods

  • Side to be treated scrubbed with acetone
  • Periorbital region treated with microdermabrasion
  • 3.0 milliliters of HA transdermally delivered per Tx approximately 5 – 10 minutes per session (Picture 2)
  • Two transdermal treatments given, 2 weeks apart
  • Mupirocin ointment immediately post-treatment
  • 2 mm punch biopsies at 4 weeks post-treatment

Results

  • Minimal and transient side effects
    - erythema (10), mild abrasions (6), purpura (1)
  • All subjects tolerated the treatments well
    - average Tolerability Score = 2.2*
  • Subject questionnaires
    - average Improvement Score = 3.2**
    • 1 = no discomfort,
    • 2 = mild discomfort,
    • 3 = moderate discomfort,
    • 4 = severe discomfort
    ** 1 = no improvement, 2 = mild improvement, 3 = moderate improvement, and 4 = dramatic improvement
  • Average change in Wrinkle Class (1 – 5) *
    - Treated Side = - 1.3
    - Control Side = - 0.2
  • Pre- and 4-week follow-up photos evaluated by four independent blinded physician observers
    - Average improvement treated side = 3.3 **
    - Average improvement control side = 1.2 **
    * As determined by blinded dermatologist reviewer
    ** 1 = no improvement,
    2 = mild improvement,
    3 = moderate improvement,
    4 = dramatic improvement

Conclusions and Implications

  • Through Dermoelectroporation®, transdermal drug delivery of HA is possible and safe
  • This concept may improve the efficiency of other biological agents and drugs such as anesthetics, anti inflammatory, and photosensitizers
  • New studies are in progress to further examine the potential scope of this process

Dr. Suneil Jain, N.M.D.

Scottsdale Natural Medicine and Healing Clinic, LLC, 8390 E. Via de Ventura Blvd. Suite F-111 Scottsdale, AZ 85258

 

Preliminary Study

To evaluate the safety, tolerability and effectiveness of transdermal delivery of a fat reduction cocktail
on abdomen, lateral thigh, medial thigh & back through Dermoelectroporation®.

Study Design

  • Toning, not obesity grade treated
  • Treatments should be administered every 2 weeks.
    Average number of treatments 3-4.
  • L-Carnitine/Phosphatidylcholine cocktail was delivered
  • Ultrapeel® Transderm® Meso System
  • Session number depending on the single patient's condition
  • Study conclusion on 90% or more resolution of the affected sites

 

Materials and Methods

Materials

1. L-Carnitine - plays an important role in fat metabolism; shuttles long chain fatty acids across the mitochondrial membrane, once inside stimulates beta oxidation
2. Phosphatidylcholine - penetrates the adipose cell, acts as a fat emulsifier by altering the stored lipids making them water soluble
3. Ultrapeel® Transderm Meso® system from Mattioli Engineering

Methods

  • Transdermal delivery of the cocktail through Dermoelectroporation® technology:
  • 2 Steps Procedure:
    a)Microdermabrasion
    b) When targeting adipose tissue:
    Transdermal delivery of the cocktail through Ultrapeel® Transderm Meso® system. In this way:
    Delivered every 1-2 weeks until desired result is achieved .Prepare solution using (2) 10 cc syringes.
    Use one syringe per respective side. Per 10 cc
    syringe:
    4 cc L-carnitine 500 mg/mL
    6 cc Phosphatidylcholine 100 mg/mL.

Application of proper follow up at the end.

Results & Conclusions

  • Patients were treated with the following results: Patients drastically reduced inches in weeks.
  • Transdermal delivery is possible and safe with no contraindications reported.
  • All patients showed a good level of improvement and she was so happy with results.

Dr. James Fulton, vivant Skin Care , Miami Florida, USA

 

Preliminary Study

To evaluate the safety, tolerability and effectiveness of transdermal delivery of Oligopeptides serum for crow’s feet treatment purposes through Dermoelectroporation®.

Study Design

  • Delivered every week for a total of 4 treatments.
  • Oligopeptides (Vivant Skin Care) was delivered
  • Ultrapeel® Transderm® Ionto Meso System
  • Repeat ideally every week until desired result is achieved.

 

Materials and Methods

Materials

1. Oligopeptides serum
Reduces Lines & Generates New Collagen 2 Ultrapeel® Transderm Ionto Meso® system from Mattioli Engineering

Methods

  • Transdermal delivery of the cocktail through Dermoelectroporation® technology:
  • 2 Steps Procedure:
    a)Microdermabrasion
    b) Transdermal delivery of :
    Prepare solution using a 10cc syringe. Use one syringe concentrating on problematic areas like the cheeks and forehead at lateral brow line.
    Per 10cc syringe
    10cc Oligopeptides

Application of proper follow up at the end.

Results & Conclusions

  • Patients were treated with the following results: Patients drastically reduced inches in weeks.
  • Transdermal delivery is possible and safe with no contraindications reported.
  • All patients showed a good level of improvement and she was so happy with results.

Report on treating the crow’s feet area through Dermoelectroporation Pn. 55100150/E Mattioli Engineering All rights reserved

Dr. Gabriela Vasilescu, M.D. Vascular Surgery Specialist, PRIM Dept - Montedomini Clinic, via de Malcontenti, 6 – 50100, Florence, Italy

 

Preliminary Study

To evaluate the safety, tolerability and effectiveness of transdermal delivery of Specific substances for skin biorevitalization purposes through Dermoelectroporation®.

Study Design

  • 3 sessions in total.
  • 1 sitting every two/three weeks.
  • Specific substances delivered
  • Ultrapeel® Transderm® Meso System
  • Severe facial muscle relaxation treated

 

Materials and Methods

Materials

  • Substances: Cosmeceuticals (Omeopatia Italiana), Antioxidants(Amway Italia).
  • Ultrapeel® Transderm Meso® system from Mattioli Engineering
  • Eufoton 808 NM Diode Laser
  • Injector U225
  • Eulite Intense Pulse Light

Methods

Session 1:
1. 10W scanner 10/12 passes laser application
After 3 days:
2. 21J IPL application with Eulite IPL.
3. Ultrapeel® Transderm Meso® system for Vitamin C and Placentex® transdermal delivery
4. Mandelic chemical Peeling for purification

Home follow up on Session 1 :
1. Application of cosmeceuticals and Antioxidants(Amway Italia)

Session 2:
1. 10W scanner 12 passes laser application
2. 21J IPL application with Eulite IPL.
3. Ultrapeel® Transderm Meso® system for Vitamin C, Placentex® and Lymdiaral transdermal delivery
4. Mandelic chemical Peeling for purification
5. Vitamins, Aminoacids and OCTICATAL thru U225
mesotherapy gun

Home follow up on Session 2:
1. Application of cosmeceuticals and Antioxidants(Amway Italia)

Session 3:
1. 10W scanner 12 passes laser application
After 3 days :
2. ICG Laserpeel application
3. 21J IPL application with Eulite IPL.
4. Ultrapeel® Transderm Meso® system for Vitamin C, Placentex® and Lymdiaral transdermal delivery
5. Mandelic chemical Peeling for purification
6. Vitamins, Amino Acids, OCTICATAL and Polynucleotides
thru U225 mesotherapy gun
7. DMAE Mandelic chemical Peeling

Home follow up on Session 2:
Application of cosmeceuticals and Antioxidants(Amway Italia)

Results & Conclusions

  • 1 patient was treated with the following results: 1 patient cleared in 1 session.
  • The subject was very happy about results
  • Transdermal delivery is possible and safe with no contraindications

Dr. Gabriela Vasilescu, M.D.

Vascular Surgery Specialist, PRIM Dept - Montedomini Clinic, via de Malcontenti, 6 – 50100, Florence, Italy

 

Preliminary Study

To evaluate the safety, tolerability and effectiveness of transdermal delivery of Specific substances for skin acne treatment through Dermoelectroporation®.

Study Design

  • 5 sessions in total.
  • 1 sitting every two/three weeks.
  • Specific substances delivered
  • Ultrapeel® Transderm® Meso System
  • Severe skin acne treated

 

Materials and Methods

Materials

Substances: Vitamin C (Omeopatia Italiana), Placentex®, (Omeopatia Italiana) Antioxidants(Amway Italia), Lymdiaral (Pascoe Italiana)
•Ultrapeel® Transderm Meso® system from Mattioli Engineering
•Eufoton 808 NM Diode Laser
•Deka Mela Italy KTP 500nm Laser
•Eulite Intense Pulse Light

Methods

Session 1, 2 and 3:
1. Microdermabrasion with sterile crystals,
2. Purifying / Regenerative Mandelic chemical peeling (30%)
3. 9W Defocalized 3 J /CMQ Diode laser application
4. Sterilization of bacterial sites thru
5. 500 nm KTP laser to be alternated with ICG Laserpeel
7W 5J Defocalized at 2,3j every 9 Sqcm.
6. IPL Application with Eulite IPL.

Home follow up on Session 1 to 3:
1. Artistry Skin Balancing programme (Amway Italia)
2. Antioxidants (Amway Italia)
3. Booster clarifying treatment (Q-Med AB (publ))
4. Candida intestinal treatment

Session 4 and 5:
1. Microdermabrasion with sterile crystals,
2. 9W Defocalized 3 J /CMQ Diode laser application
3. Sterilization of bacterial sites thru
4. 500 nm KTP laser
5. Ultrapeel® Transderm Meso® system for Vitamin C, Placentex® and Lymdiaral transdermal delivery

Home follow up on Session 4 and 5:
1. Artistry Skin Balancing programme (Amway Italia)
2. Antioxidants(Amway Italia)
3. Booster clarifying treatment(Q-Med AB (publ)
4. Candida intestinal treatment

Results & Conclusions

  • 1 patient was treated with the following results: 1 patient cleared in 1 session.
  • The subject was very happy about results
  • Transdermal delivery is possible and safe with no contraindications

Dr. Suneil Jain, N.M.D.

Scottsdale Natural Medicine and Healing Clinic, LLC, 8390 E. Via de Ventura Blvd. Suite F-111 Scottsdale, AZ 85258

 

Preliminary Study

To evaluate the safety, tolerability and effectiveness of transdermal delivery of a Hyaluronic Acid cocktail on Perioribital & Perioral Areas through Dermoelectroporation®.

Study Design

  • Fine to medium lines of the face
  • Treatments should be administered every 2 weeks for 3 treatments. Thereafter every 6-8 weeks for maintenance.
  • L-Carnitine/Phosphatidylcholine cocktail was
    delivered
  • Ultrapeel® Transderm® Meso System
  • Session number depending on the single patient's condition
  • Study conclusion on 90% or more resolution

 

Materials and Methods

Materials

1. Hyaluronic Acid - plays an important role in tissue hydration, lubrication and cellular function; removes wastes from cells with no direct blood supply; able to hold more water than any other natural substance which results in smoothness, softening and decrease in wrinkles

2. Glutathione - “master antioxidant”; acts to reconstitute Vitamin C and E after they have been oxidized; protects cells from free radical damage; works in conjunction with Super Oxide Dismutase (enzymes that play a major role in the protection of cells from oxidative stress) to help with detoxification

3. MTE-4 – contains 4 multi-trace elements

a. Copper: important for conversion of Ltyrosine to melanin aiding in UV protections; needed for conversion of carotene to retinol; needed for CT maturation; provides cross-linking of aldehydes in collagen and elastin tissues; stimulates SOD enzyme

b. Manganese: activates enzymes in formation of collagen; tones & firms skin

c. Zinc Sulfate: required for synthesis of collagen; protects against UV rays; stimulates transport of Vitamin A from liver to skin; stimulates SOD enzyme d. Chromium: can help with acne by improving localized glucose sensitivity 4.Ultrapeel® Transderm Meso® system from Mattioli Engineering

Methods

  • Transdermal delivery of the cocktail through Dermoelectroporation® technology:
  • 2 Steps Procedure:
    a)Microdermabrasion
    b) When targeting adipose tissue:
    Transdermal delivery of the cocktail through Ultrapeel® Transderm Meso® system. In this way. Deliver every 2 weeks for 3 treatments. Thereafter every 6-8 weeks for maintenance. Prepare solution using a 10 cc syringe. After combining the ingredients transfer half of the solution to another 10 cc syringe. Use 1 syringe per side of the face.
    2 cc Sodium Hyaluronate 25 mg/mL
    2 cc Glutathione 100 mg/mL
    2 cc MTE 4 containing: (1 mg copper, 0.5 mg manganese, 10 mcg chromium, 22 mg zinc sulfate) per mL

Application of proper follow up at the end

Results & Conclusions

  • Patients were treated with the following results: Patients drastically reduced inches in weeks.
  • Transdermal delivery is possible and safe with no contraindications reported.
  • All patients showed a good level of improvement and she was so happy with results.

Dr. A.Gessati*,

*Aesthetic medicine Doctor, Milan, Italy.

 

Preliminary Study

Dermoelectroporation, well known and established method for transdermal substances delivery without the use of needles, promote the opening of membrane channels and allows the transdermal delivery of Hyaluronic acide based bio revitalizing and growth factor cocktails.
The LED stimulation provokes , due to a controlled , low intensity, ionizing light radiation, a biological response from the treated tissues. The procedure consists of a skin-compatible proteins transdermal delivery to improve the cellular cleaning and the restoration of microcirculation pathways in order to get a fast improvement on the external skin tissues.

Study Design

  • 10 patients were treated on 5 sessions - once per week.
  • Follow up after one month
  • Revitalase (Mattioli engineering -Italy)
  • Ultrapeel® Transderm® Meso System
  • 15mins application each session (AVG).
  • Treated areas : Per oral area.

 

Materials and Methods

Materials

  • Revitalase (Mattioli engineering)
  • Ultrapeel® Transderm® Meso System(Mattioli engineering)
  • L.E.D. Photo Stimulation device

Methods

  • Pre-Sterilised corundum crystals Microdermabrasion up to reach a strong
    hyperemia.
  • Transdermal delivery of 3cc Revitalase – (
  • Hyaluronic acid enriched by Tissue Growth Factors)cocktail
  • LED Photo-biomodulation 633+/-6 nm.
  • 1 session per week for a total of 5 sessions depending on the single patient.
  • Follow up after 1 month.

Results

  • Significant decreasing of the patient’s smoker’s lines on the selected areas.
  • Result Assessment : Good according to single
    patient’s satisfaction grade.

Conclusions

The present study proved the transdermal delivery of Revitalase through Ultrapeel® Transderm® Meso System is safe, possible and effective.
The administer therapy is:
- Easy to perform.
It doesn’t show up any problem either during or after the administration
It is well tolerated by the patient.
This methodology:
- non invasive.
- Pain Free.
- No side effect reported.

Report on smoker’s face lines treatment through Dermoelectroporation Pn. 55100120/E Mattioli Engineering All rights reserved

Dr. James Fulton, vivant Skin Care , Miami Florida, USA

 

Preliminary Study

To evaluate the safety, tolerability and effectiveness of transdermal delivery of a cellulitic serum for localized fat deposits reduction purposes through Dermoelectroporation®.

Study Design

  • Delivered every 1 weeks for a total of 8 treatments.
  • Cellulitic serum 5% (Vivant Skin Care) was delivered
  • Ultrapeel® Transderm® Ionto Meso System
  • Repeat ideally every week until desired results is achieved

 

Materials and Methods

Materials

  1. Cellulitic serum 5 Dissolves Localized Fatty deposits
  2. Ultrapeel® Transderm Ionto Meso® system from Mattioli Engineering

Methods

  • Transdermal delivery of the cocktail through Dermoelectroporation® technology:
  • 2 Steps Procedure:
    a)Microdermabrasion
    b) Transdermal delivery of:
    Prepare solution using (2) 10cc syringe. Use one syringe per area being treated, concentrating on problematic areas. Areas are referred to as abdomen, lateral thigh, medial thigh, back, arms, etc.
    Per 10cc syringe
    10cc Cellulolytic Serum

Application of proper follow up at the end.

Results & Conclusions

  • Patients were treated with the following results:
    Patients drastically reduced inches in weeks.
  • Transdermal delivery is possible and safe with no contraindications reported.
  • All patients showed a good level of improvement and she was so happy with results.

Report on Localized Fat Deposits treatment through Dermoelectroporation Pn. 55100220/E Mattioli Engineering All rights reserved

Dr. James Fulton, vivant Skin Care , Miami Florida, USA

 

Preliminary Study

To evaluate the safety, tolerability and effectiveness of transdermal delivery of Oligopeptides serum for crow’s feet treatment purposes through Dermoelectroporation®.

Study Design

  • Delivered every week for a total of 4 treatments.
  • Oligopeptides (Vivant Skin Care) was delivered
  • Ultrapeel® Transderm® Ionto Meso System
  • Repeat ideally every week until desired result is achieved.

 

Materials and Methods

Materials

  1. Oligopeptides serum
    Reduces Lines & Generates New Collagen
  2. Ultrapeel® Transderm Ionto Meso® system from Mattioli Engineering

Methods

  • Transdermal delivery of the cocktail through Dermoelectroporation® technology:
  • 2 Steps Procedure:
    a)Microdermabrasion
    b)Transdermal delivery of:
    Prepare solution using a 10cc syringe. Use one syringe concentrating on problematic areas like the cheeks and forehead at lateral brow line.
    Per 10cc syringe
    10cc Oligopeptides

Application of proper follow up at the end.

Results & Conclusions

  • Patients were treated with the following
    results: Patients drastically reduced inches in weeks.
  • Transdermal delivery is possible and safe with no contraindications reported.
  • All patients showed a good level of improvement and she was so happy with results.

Dr. Gabriela Vasilescu, M.D.

 

Preliminary Study

To evaluate the safety, tolerability and effectiveness of transdermal delivery of an Hydrating cocktail for skin aging treatment through Dermoelectroporation®.

Study Design

  • 5 sessions in total.
  • 1 sitting every three weeks.
  • Hydrating cocktail delivered
  • Ultrapeel® Transderm® Meso System
  • Severe skin aging treated

 

Materials and Methods

Materials

  • (VTF), Hyaluronic Acid, Vitamins, DMAE and antioxidants
  • Ultrapeel® Transderm Meso® system from Mattioli Engineering

Methods

  • Transdermal delivery of the Hydrating cocktail through Dermoelectroporation® technology:
  • 5 sessions in total:
    1st session Microdermabrasion and VTF only.
    2nd to 5th performed in two phases:
    Phase 1: Microdermabrasion (MDA) and transdermal delivery of Hydrating substances (VTF), Hyaluronic Acid, Vitamins, DMAE and antioxidants (in the third and fourth session, perform Citric mandelic peeling after MDS and then VTF).
    Phase 2: Diode Laser 808 nm, treatment with con 10/12W rotating scanner
    1 sitting every 3 weeks alternated with one sitting for skin stimulating every 10 days (laser & laserpeel with green coloration indocyanine; preliminary MDA and VTF); Total time to treatment 1 hour or so.

Application of proper SPF at the end.

Results & Conclusions

  • 1 patient was treated with the following results:
    1 patient cleared in 1 session.
  • The subject was very happy about results
  • Transdermal delivery is possible and safe with no contraindications reported.
  • The patient showed a good level of improvement and she was so happy with results.

 

Dr. A.Gessati*,
*Aesthetic medicine Doctor, Milan, Italy.

 

Preliminary Study

Dermoelectroporation, well known and established method for transdermal substances delivery without the use of needles, allows to get to important results for skin imperfection conditions, such as the inner arm areas relaxation (with the formation of bands of tissue in excess), which are often solved only through surgical methods. The correction of excessively relaxed skin, related to the loss of elastic features and support, requires biorevitalizing substances transdermal delivery(REVITALASE) commonly injected through a syringe, due to Ultrapeel Transderm Meso system device endorsing Dermoelectroporation technology. We developed an operating protocol Synergyzing the effect of biostimulanting substances driven through the skin with LED device(OMNILUX REVIVE 633 nm) able to to affect the cellular response.

Study Design

  • 5 patients were treated to follow-up every week.
  • Revitalase from Mattioli engineering -Italy)
  • Ultrapeel® Transderm® Meso System
  • Weekly Session (depending on the single patient's condition) for a total of 5 to 8 sessions.
  • 20mins application each session (AVG).
  • Treated areas: Hips, legs and abdomen.

 

Materials and Methods

Materials

  • Revitalase (Mattioli engineering)
  • Ultrapeel® Transderm® Meso System(Mattioli engineering)

Methods

  • Pre-Sterilised corundum crystals Microdermabrasion up to reach a strong hyperemia.
  • Transdermal delivery of REVITALASE – (Hyaluronic acid enriched by Tissue growth factors)
  • Red LED Photo-biomodulation 633+/-6 nm.
  • 1 session per week for a total of 5-8 sessions depending on the single patient.

Results

Significant decreasing of the patient’s cellulite sections and areas.
Result Assessment: Good according to single patient’s satisfaction grade.

Conclusions

The present study proved the transdermal delivery of Revitalase through Ultrapeel® Transderm® Meso System is safe, possible and effective.

The administer therapy is:

  • Easy to perform. It doesn’t show up any problem either during or after the administration. It is well tolerated by the patient.

 

This methodology:

  • Non invasive.
  • Pain Free.
  • No side effect reported.

Dr. James Fulton, vivant Skin Care , Miami Florida, USA

 

Preliminary Study

To evaluate the safety, tolerability and effectiveness of transdermal delivery of a Hyaluronic Acid & Oligopeptides cocktail
for either facial lifting and finelines reduction purposes through Dermoelectroporation®.

Study Design

  • Delivered every 1 or 2 weeks for a total of 8
    treatments.
  • Oligopeptides with Hyaluronic acid gel (Vivant Skin
    Care) was delivered
  • Ultrapeel® Transderm® Ionto Meso System
  • Repeat ideally every 12 week

 

Materials and Methods

Materials

  1. Oligopeptides serum 10% Reduces Lines & Generates New Collagen
  2. Hyaluronic acid serum 1% Fills out the Dermis and Hydrates the Joints
  3. Ultrapeel® Transderm Ionto Meso® system from Mattioli Engineering

Methods

  • Transdermal delivery of the cocktail through Dermoelectroporation® technology:
  • 2 Steps Prodecure:
    • a) Microdermabrasion
    • b) Transdermal delivery of:
      Prepare solution using a 10cc syringe. Use 5cc’s per side of the face, concentrating on problematic areas like the cheeks and forehead at lateral brow line.
      Per 10cc syringe
      5cc Oligopeptides
  • Application of proper follow up at the end.

Results & Conclusions

  • Patients were treated with the following results: Patients drastically reduced inches in weeks.
  • Transdermal delivery is possible and safe with no contraindications reported.
  • all patients showed a good level of improvement and she was so happy with results.

Report on Hyaluronic Acid and oligopeptides cocktail treatment through Dermoelectroporation Pn. 55100200/E Mattioli Engineering All rights

Dr. Gabriela Vasilescu, M.D.

Vascular Surgery Specialist, Martelli clinic, via del Bersaglio, 7 – Florence, Italy

 

Through Dermoelectroporation, the one and most innovative method for transdermal delivery of water based active ingredients into the body without needles, very important results have been achieved when fighting skin imperfections, elder and actinic keratosis normally cancelled using surgery.All our experiences in treating Actinic keratosis thru Dermoelectroporation have been carried out through the dose of a microdermabrader (till medium Hyperemia) and Transdermal delivery of skin regeneration ingredients (Placentex Mastelli), amino acids, Hyaluronic acid normally injected by syringes, driven through Transderm endorsing Dermoelectroporation. Technology.

Actinic Keratosis Protocol

  • Pre Sterilised crystals Microdermabrasion on the targeted area until a medium Hyperemia is reached
  • Transdermal delivery of 1 vial of Placentex not diluted, 2 cc of amino acids, 2 cc Hyaluronic Acid
  • 808 nm diode Laser for Photo Thermal lysis
  • 1 session every 15 days for a total of 4 sessions

Results & Conclusions

  • 1patient was treated with the following results:
    • 1 patient cleared in 1 session
    • The subject was very happy about results
    • Transdermal delivery is possible and safe with no contraindications reported
    • The patient showed a good level of improvement and she was so happy with results
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