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Report on smoker’s face lines treatment through Dermoelectroporation

February 14, 2022

Dr. A.Gessati*,

*Aesthetic medicine Doctor, Milan, Italy.


Preliminary Study

Dermoelectroporation, well known and established method for transdermal substances delivery without the use of needles, promote the opening of membrane channels and allows the transdermal delivery of Hyaluronic acide based bio revitalizing and growth factor cocktails.
The LED stimulation provokes , due to a controlled , low intensity, ionizing light radiation, a biological response from the treated tissues. The procedure consists of a skin-compatible proteins transdermal delivery to improve the cellular cleaning and the restoration of microcirculation pathways in order to get a fast improvement on the external skin tissues.

Study Design

  • 10 patients were treated on 5 sessions – once per week.
  • Follow up after one month
  • Revitalase (Mattioli engineering -Italy)
  • Ultrapeel® Transderm® Meso System
  • 15mins application each session (AVG).
  • Treated areas : Per oral area.


Materials and Methods


  • Revitalase (Mattioli engineering)
  • Ultrapeel® Transderm® Meso System(Mattioli engineering)
  • L.E.D. Photo Stimulation device


  • Pre-Sterilised corundum crystals Microdermabrasion up to reach a strong
  • Transdermal delivery of 3cc Revitalase – (
  • Hyaluronic acid enriched by Tissue Growth Factors)cocktail
  • LED Photo-biomodulation 633+/-6 nm.
  • 1 session per week for a total of 5 sessions depending on the single patient.
  • Follow up after 1 month.


  • Significant decreasing of the patient’s smoker’s lines on the selected areas.
  • Result Assessment : Good according to single
    patient’s satisfaction grade.


The present study proved the transdermal delivery of Revitalase through Ultrapeel® Transderm® Meso System is safe, possible and effective.
The administer therapy is:
– Easy to perform.
It doesn’t show up any problem either during or after the administration
It is well tolerated by the patient.
This methodology:
– non invasive.
– Pain Free.
– No side effect reported.

Report on smoker’s face lines treatment through Dermoelectroporation Pn. 55100120/E Mattioli Engineering All rights reserved