Dr. Suneil Jain, N.M.D.

Scottsdale Natural Medicine and Healing Clinic, LLC, 8390 E. Via de Ventura Blvd. Suite F-111 Scottsdale, AZ 85258

Preliminary Study

To evaluate the safety, tolerability and effectiveness of transdermal delivery of a cellulite reduction cocktail on Thighs, Abdomen, Gluteus & Knees through Dermoelectroporation®.

Study Design

• Grades 1-2, some 3 were treated
• Treatments should be administered every 2 weeks.
• Average number of treatments 5-8.
• Hyaluronidase /L-Carnitine/Phosphatidylcholine cocktail was delivered
• Ultrapeel® Transderm® Meso System
• Session number depending on the single patient’s condition
• Study conclusion on 90% or more resolution of the affected sites

Materials and Methods

Materials

1. L-Carnitine – plays an important role in fat metabolism;
   shuttles long chain fatty acids across the mitochondrial
   membrane, once inside stimulates beta oxidation
2. Phosphatidylcholine – penetrates the adipose cell, acts
   as a fat emulsifier by altering the stored lipids making them
   water soluble
3. Hyaluronidase – naturally occurring enzyme that helps
   break up connective tissue bonds that create dimpling
   effect
4. Ultrapeel® Transderm Meso® system from Mattioli Engineering

Methods

• Transdermal delivery of the cocktail through Dermoelectroporation® technology:
• 2 Steps Prodecure:
  a)Microdermabrasion
  b) When targeting adipose tissue:
  Transdermal delivery of the cocktail through Ultrapeel®
  Transderm Meso® system. In this way:
  Delivered every 1-2 weeks until desired result is achieved.
  Prepare solution using (2) 10 cc syringes. Use one syringe per respective side. Areas are referred to as abdomen,
  thighs, etc.
  Per 10 cc syringe:
  4 cc Hyaluronidase 300 units/mL
  4 cc L-carnitine 500 mg/mL
  2 cc Phosphatidylcholine 100 mg/mL

Application of proper follow up at the end.

Results & Conclusions

• Patients were treated with the following results: Patients drastically reduced inches in weeks.
• Transdermal delivery is possible and safe with no contraindications reported.
• All patients showed a good level of improvement and she was so happy with results.